Refer for the ENDOSURE Diagnostic Test

Fax this form to the patient’s preferred ENDOSURE test location.

Download Referral Form

The Only Tier 1 Diagnostic Test for Endometriosis

Canadian clinics offering ENDOSURE Test

Clinic Location Lead Provider Phone Fax
Links Medical Clinic Edmonton, AB (Mira Health Centre, #109 – 11910 111 Ave NW) Dr. Sam Azer, OBGYN +1 (780) 454-0351 +1 (780) 429-0372
CReATe Fertility London London, ON (215 Fanshawe Park Road West, Suite 10) Dr. John McNaught, OBGYN +1 (519) 472-9333 +1 (519) 286-0277
The ENDO Health Collective Vancouver, BC (Unit 410, 943 West Broadway​) Shani DeShield, RN, NP, Family/All Ages +1 (778) 300-5177 +1 (888) 834-3174

3-minute ENDOSURE Test

Practitioner Webinar

  1. ENDOSURE test, by 3CPM, is authorized for sale by Health Canada, MDALL 107153
  2. Provides clinical decision support for earlier diagnosis of endometriosis
  3. Most like ECG, but for the gut. Electroviscerography/EVG captures the GIMA biomarker of endometriosis 
  4. Tier-1 test; non-invasive, rapid, accurate, suitable for all ages, detects all disease stages
Referral Form

PRIMARY CARE PROVIDERS & SPECIALISTS

Rapid Diagnosis for Endometriosis

TIER-1 testing could be considered for patients experiencing:

  • Dysmenorrhea, chronic pelvic pain
  • Menorrhagia
  • Dysuria, dyschezia, or dyspareunia
  • IBS, GI issues, suspected urinary infection unresponsive to treatment
  • Unexplained fatigue, brain fog, anxiety, or depression
  • Unexplained infertility, frequent miscarriage, or previous high-risk pregnancy
Canadian Clinics Now Offering ENDOSURE
Hover over (or click) on any marker on the map to find clinic contact information and a link to book your test or to refer a patient. Interested in bringing ENDOSURE to your clinic or practice? Give us a call or send us a message.

DIAGNOSTIC SUPPORT for ENDOMETRIOSIS

  • Patients under 36: 99% accuracy, 95% sensitivity, 96% specificity
  • Patients 36+: 98% accuracy, 91% sensitivity, 95% specificity
  • Detects all disease stages
  • Detects all disease subtypes & adenomyosis

PATIENT CENTRED

  • For all ages, premenarche to post menopause
  • Painless & trauma informed
  • Minimal patient preparation
  • Patients remain fully clothed during test
  • Testing takes less than an hour

Clinical Uses

  • Rapid diagnosis
  • Post treatment patient monitoring
  • Confirming factor for infertility
  • Adolescent screening

ENDOSURE provides clinical evidence If You suspect endometriosis

TIER-1 Diagnostic Test for Endometriosis

ENDOSURE is a highly accurate, yet non-invasive test that uses an electroviscerography system (EVG), an analytical instrument that collects Gastro Intestinal Myoelectrical Activity (GIMA) signals from the abdomen through dry electrodes. The test detects endometriosis presence by measuring a GIMA pattern unique to endometriosis sufferers, known as the GIMA biomarker of endometriosis. Very similar to an electrocardiogram/ECG it’s easy to perform and provides a near-instant diagnostic result using simple, objective GIMA data.

ENDOSURE test, by 3CPM, is authorized for sale by Health Canada (MDALL 107153).

ENDOSURE is a private test and not currently covered by provincial healthcare plans in Canada. Blue Cross has added ENDOSURE test coverage under extended health care plans, including fertility and family planning benefits (with referral) and through health spending accounts (HSAs) and personal spending accounts; Sunlife has added coverage for some fertility/family planning plans. Because coverage requirements, reimbursement limits, and referral criteria vary by plan, patients should review their benefits and contact their insurance provider to confirm eligibility and determine whether a healthcare provider referral or letter of support is required before scheduling the test.

Information for Providers

   Patient Brochure

  Talk to Us

Electroviscerography system (EVG) is an analytical instrument that collects
myoelectrical activity signals from the gastrointestinal tract (GIMA).

ENDOSURE test records patient GIMA pattern over 30-minutes, then compares data to the GIMA biomarker of endometriosis, a known digital “fingerprint” of people who suffer from endometriosis.2,3

Near-instant results support your diagnosis of endometriosis and expedite disease management. 

Frequently Asked Questions

What should patients expect?

Testing is painless and takes just under an hour. Similar to an ECG but for the gut: electrodes record gastrointestinal myoelectric activity (GIMA) for 30 minutes while patient remains still and relaxed.

When should patients schedule an ENDOSURE test?

Scheduling ENDOSURE Test:

  • Non-menses
  • ≥2 wk post-acute GI illness
  • ≥2 wk post-abdo/pelvic infection
  • ≥3 mo post-abdo/pelvic surgery
  • Stable/No active: celiac/crohns/ulcerative colitis/ SIBO/bowel obstruction/
    GI infection sx
What are guidelines for medication restrictions for patients preparing for testing?

NPO 8h pre-EVG. Hold opioids/lisdexamfetamine x48h; antispasmodics/prokinetics/bowel stimulants x72h; THC/GLP-1 agonistsx30d pre-EVG. Cont APAP/NSAIDs/hormonal tx/antidepressants/neuropathic pain meds/antiemetics PRN. 

What if a patient is diabetic?

Patient preparation includes: 

-NPO 2-hours pre-test 

-2-8h pre-test, allow small snack – 4oz apple/grape juice + 1 dry toast slice OR 2 rice cakes. NPO ≥2h pre-test.

– Continue all routine Rx meds unless specified otherwise. Take w/ small sips H2O if needed. NPO ≥2h pre-test.

Other instructions remain the same:

-NPO MN caffeine 

-Hold opioids x 48h pre-EVG 

-Hold antiemetics/antispasmodics/prokinetics/THC x 72h pre-EVG 

 

What medications can affect the ENDOSURE test?
  • Opioid pain medications that slow the bowel: Codeine, Oxycodone, Hydrocodone +/- acetaminophen, Morphine, hydromorphone, Tramadol +/- acetaminophen
  • ADHD medications containing lisdexamfetamine (Vyvanse)
  •  Medications that change intestinal movement: Metoclopramide, Domperidone, Itopride, Levosulpiride, Erythromycin, Dicyclomine, Hyoscine butylbromide, Loperamide
  • THC containing cannabis products
  • GLP-1 receptor agonists that slow stomach emptying: Tirzepatide – Mounjaro, Semaglutide – Ozempic/Wegovy
What medications are usually safe to continue during an ENDOSURE test?

Acetaminophen, NSAIDs, Hormonal contraceptives, Endometriosis hormone therapy, Antidepressants, Neuropathic pain medication, Antiemetics

Can patients continue with medical marijuana?

Preparations containing THC should be discontinued 30 days prior to ENDOSURE testing.

Do I receive test results?

On the referral form, check the box to request ENDOSURE test results.

Who reviews test results with patients?

Patients generally book a separate consult with the testing clinics attending clinician to review results. 

Can I rely on ENDOSURE test results?

ENDOSURE test is a highly accurate clinical tool helping clinician confidently diagnose endometriosis. Draft Guidelines from NICE (UK) now include ENDOSURE test as a first line test for endometriosis. Published results are as follows:

Females ≤35 years:

  • 99% accurate
  • 95% sensitivity
  • 96% specificity

Females 36 years+:

  • 98% accurate
  • 91% sensitivity
  • 95% specificity
Is the ENDOSURE test covered by provincial healthcare plans?

ENDOSURE test is only available at private clinics and is not currently covered by provincial plans (e.g. AHCIP, OHIP).

Is the ENDOSURE test covered by insurance?

Insurance coverage of ENDOSURE test is available under select Blue Cross extended health care plans, including fertility and family planning benefits (with a referral for testing) and through health spending accounts (HSAs) and personal spending accounts; SunLife offers coverage within plans that cover Endometrial Receptivity Assessment (ERA). Coverage requirements, reimbursement limits, and referral criteria vary by insurance company and plan. Patients should review their benefits and contact their insurance provider to confirm eligibility and determine whether a healthcare provider referral or letter of support is required before scheduling the test. Reimbursement normally requires a referral before testing from thier clinician.

What are the most common endometriosis symptoms?
  • Dysmenorrhea, Chronic pelvic pain
  • Menorrhagia
  • Dysuria, Dyschezia, or Dyspareunia
  • IBS, GI issues, suspected urinary infection unresponsive to treatment
  • Unexplained fatigue or Brain fog
  • Anxiety or depression
  • Unexplained infertility
  • Frequent miscarriage
  • Previous high-risk pregnancy
Are there any risks associated with ENDOSURE?

There are no risks associated with this test. There are no components that are used during the test equipment that are harmful. No anesthesia is required for this test.

What Clinicians are Saying

“We’ve not seen any real movement in the treatments and the diagnosis of endometriosis for like two decades and now it’s all seems to be coming together. It’s a combination of the ENDOSURE test and the new drugs, which is going to change the management for many of these young women.”
- Dr. David Griffiths, Consultant Gynaecologist MB ChB, FRCOG

“ Until now we haven’t had a very good, simple, easy, quick, inexpensive screening test for endometriosis. Until now the only way to diagnose endometriosis definitively has been with a surgical procedure. We have the potential to crack that nut.

Larry Glazerman, MD, MBA
“If patients understand why they’re experiencing symptoms, it helps them cope, reduces stress, and creates closure so they can move forward with appropriate treatment. ENDOSURE testing provides that clarity in minutes rather than years.”
-Dr. Sarah Roth, ND

ENDOSURE, the only Tier 1 test for endometriosis

The Science

Endometriosis causes unusual contractile patterns in the small bowel due to higher than normal serum levels of prostaglandins secreted by endometriosis tissues, despite disease location; peritoneal, ovarian, extra pelvic or intrauterine. While normal ranges of gut contractions are 1-12 cycles per minute (CPM) in healthy women, prostaglandins cause uncontrolled high-frequency contractions ranging from 15-200 CPM when endometriosis is present. This causes many of the painful symptoms associated with endometriosis.

The ENDOSURE Test objectively collects this gut seizure activity using EVG, then compares a patient’s GIMA profile to the “GIMA biomarker” for endometriosis to detect disease presence. In clinical studies, the test has 99% accuracy (98% accuracy for patients 36 years+) in surgically verified studies, reflecting a strong ability to distinguish between positive and negative cases.1

ENDOSURE test results offer clinical decision support, when endometriosis is suspected. With testing more like an ECG, Tier 1 diagnostic testing for endometriosis is now fast, easy, safe and accurate.

Learn More

GET STARTED

offer endosure testing at your clinic

Join the revolution in endometriosis care. Offer your patients fast, accurate answers about endometriosis with ENDOSURE.

1. Fill out the contact form

Check your email for instant resources & next steps.

2. Meet with our team

Book an online meeting with out CEO Maria Porcellato and COO Carolyn Plican

3. In-clinic Demo

Decide if ENDOSURE testing fits your clinic with a live demonstration, ​while providing training for your staff.

4. Start offering ENDOSURE testing

We continue to work with your clinic to make your program a success – including ongoing staff training & certification and clinic level marketing support!

CONTACT FORM

Published Research: 

1. Mark Noar, John Mathias, Ajit Kolatkar. Validation of New GIMA Biomarker Signature of Endometriosis – Interim Data: Research Article. Advance. August 26, 2024.
DOI: 10.22541/au.172469630.08159498/v1

2. Noar M, Mathias J, Kolatkar A. Gastrointestinal Myoelectrical Activity (GIMA) Biomarker for Noninvasive Diagnosis of Endometriosis. J Clin Med. 2024;13(10):2866. Published 2024 May 13. doi:10.3390/jcm13102866

3. AI-Derived Threshold Score of Intraabdominal Myoelectrical Activity Predicts Presence and Stage of Endometriosis with 100% Accuracy, Noar, M., Journal of Minimally Invasive Gynecology, Volume 29, Issue 11, S4 – S5. DOI: 10.1016/j.jmig.2022.09.026

4. Tanos P, Donders F, Massaro A, Philippe S, Karampelas S. Defining the role of the gastrointestinal myoelectrical activity (GIMA) biomarker in the diagnosis of endometriosis. J Minim Invasive Gynecol. 2025;32(11)(suppl):S23. doi:10.1016/j.jmig.2025.09.027

LONDON, ONTARIO

CReATe Fertility London

CReATe Logo

Phone: +1 519-472-9333

Fax: +1 519-286-0277

Address: 215 Fanshawe Park Rd W, London ON N6G 5A9

CReATe Fertility Centre offers comprehensive fertility care for individuals and families, specializing in advanced treatments such as IVF and ICSI. As a leading fertility specialist in Southern Ontario, our mission is to deliver the most natural, safe, and affordable approach to fertility care. Please phone the clinic to inquire about ENDOSURE testing

Medical Director
Dr. John McNaught, FRCSC, OB/GYN, MD

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EDMONTON, ALBERTA

Links Clinic

Links Medical Clinic Logo

Phone: +1 (780) 454 – 0351

Fax: +1 (780) 429-0372

Email: info@linksclinic.ca

Referral Form

Address:Mira Health Center, #109 – 11910 111 Avenue NW, Edmonton, Alberta, T5G 0E5

Dr. Azer provides specialist-level assessment and care for both routine and complex gynecologic issues, including endometriosis. Please call the clinic to inquire about testing. Referrals are accepted from both family physicians, and specialists. If you do not have a family physician, referrals are accepted from a walk-in clinic. Referrals can be faxed: to +1 (780) 429-0372.

Medical Director
Dr. Sam Azer, OBGYN , MD

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VANCOUVER, BC

The Endo Health Collective

The Endo Health Collective Logo

Phone: +1 778-300-5177

Fax: + 1 888-834-3174

Email: hello@theendohealthcollective.ca

Address: Unit 410, 943 West Broadway, Vancouver, BC, V5Z 4E1

Book ENDOSURE test

The Endo Health Collective is a Vancouver, BC diagnostic and women’s health care clinic focused on endometriosis. Led by Shani DeShield, RN, NP (Family/All Ages), the clinic combines family medicine, fertility charting, dedicated endometriosis consulting, acupuncture, pelvic floor physiotherapy, naturopathy, and Traditional Chinese Medicine. Referrals are accepted from both family physicians, and specialists. If you do not have a family physician, referrals are accepted from a walk-in clinic. If you would like to self-refer, please call our clinic directly.

Medical Director
Shani DeShield, RN, NP, Family/All Ages

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